The U.S. designated Hassan Irloo, whom it described as “an official in Iran’s Islamic Revolutionary Guard Corps-Quds Force (IRGC-QF) and the Iranian regime’s envoy to the Huthi rebels in Yemen” on counterterrorism authorities. Secretary of State Mike Pompeo argued that “by dispatching Irloo to Yemen, the IRGC-QF is signaling its intent to increase support to the Huthis and further complicate international efforts to reach a negotiated settlement to the conflict”. The U.S. also sanctioned “Al-Mustafa International University for facilitating IRGC-QF recruitment efforts and one individual”. According to the Treasury Department, the university “is used as a recruitment platform by the IRGC-QF for intelligence collection and operations, including recruitment for the IRGC-QF-led foreign militias fighting on behalf of Bashar al-Assad’s regime in Syria”. The following day, Iran blacklisted the U.S. ambassador to Yemen for having “a leading role in organising, financing and arming, directing and carrying out actions of aggressor coalition and formation of human tragedy in Yemen”.

Syrian Foreign Minister Feisal Meqdad visited Tehran and met with Foreign Minister Javad Zarif and other senior officials. Discussing the trip, Iran’s diplomatic spokesperson maintained that “political solutions are the only possible option to end the current crisis” in Syria and affirmed that “Iran stands beside the Syrian people and the government in the fight against terrorism”. The following day, President Rouhani called Syrian a “strategic ally” and asserted that Israel “must be confronted until the liberation of the occupied territories, including Golan Heights”. Iran’s Defence Minister, Amir Hatami, also voiced “the determination of Iran to continue cooperation with Syria in the reconstruction phase of this country”.

Secretary Pompeo announced that “the Department of State and the Department of the Treasury sanctioned nineteen individuals and entities under the Caesar Syria Civilian Protection Act of 2019 and other sanctions authorities”. “The Assad regime has a choice: take irreversible steps toward a peaceful resolution of this decade-long conflict or face further crippling sanctions”, Pompeo asserted.

The spokesperson for the counter-ISIS coalition underscored that “a key part of the mission to defeat Daesh falls on the coalition members and our partners in the Al-Tanf Garrison. Protection of this terrain keeps Daesh and other outlaw groups from using this region”. “CJTF-OIR is committed to maintaining the security in and around Al-Tanf Garrison”, the spokesperson asserted. 

The U.S. ambassador to the UN told the Security Council that “the Assad regime continues to give Iran and its military proxies safe harbour to extend their terror campaign and project its military power deeper into the Middle East, threatening the lives of the Syrian people, but also the security of Israel”. She further asserted that “Iranian forces must withdraw from Syria for there to be lasting peace. Only the UN-facilitated political solution outlined in Resolution 2254 will pave the way for Syria at peace with its people and the region”.

President Bashar al-Assad maintained that “we can only have normal relations with Israel when we have our land back. It’s very simple. So, it is possible when Israel is ready and Israel is not ready. It has never been ready”. He also asserted that “we don’t have Iranian troops [in Syria]… They support Syria, they send their military experts, they work with our troops on the ground, the exist with the Syrian army”. “The Iranian issue is a pretext for occupying Syrian land and supporting terrorists”, Assad insisted.

The U.S. unveiled “seventeen Syria sanctions designations as part of the Administration’s continuing campaign to achieve the goals of the Caesar Syria Civilian Protection Act of 2019 and hold Assad and his enablers accountable for their crimes”.

CENTCOM Commander Kenneth McKenzie confirmed that “we’re in two positions in Syria… in the Eastern Syria Security Area, we got more than 500 people that are working that area. And we’ve got a couple hundred down in the al-Tanf Garrison”. He further underscored that “we’re not doing any fighting in there. We are in there to support our SDF partners and the military objective we’re in there is to finish the final defeat of ISIS up and down the Euphrates River Valley… At the same time, we’re there to assist the SDF and holding the oil fields that are there as well to prevent ISIS from recapturing those oil fields and allow the SDF ultimately perhaps to recoup some of the benefits of those oil fields”.

Syrian state media reported Israeli airstrikes “from the side of al-Tanf into the direction of T-4 airport” near Homs, causing material damage but no casualties. Media reports indicated that additional suspected Israeli strikes targeted sites in Deir al-Zour province, purportedly killing “sixteen Iraqi paramilitary fighters loyal to Iran”.

On the sidelines of a Syrian Constitutional Committee meeting in Geneva, Iran, Russia and Turkey “reaffirmed their strong commitment to the sovereignty, independence, unity and territorial integrity of the Syrian Arab Republic”. They further voiced “their opposition to the illegal seizure and transfer of oil revenues that should belong to the Syrian Arab Republic”, and “condemned the continuing Israel’s [sic] military attacks in Syria”.

The U.S. Special Representative for Syria, James Jeffrey, reiterated that “our goals [in Syria] remain as they have been for years: the enduring defeat of ISIS and al-Qaeda, an irreversible political solution to the Syrian conflict in line with UN Security Council Resolution 2254 and the removal of all Iranian-commanded forces. We are maintaining our maximum political and economic pressure for these goals… Our policy isn’t regime change; our policy is a change in behavior of whoever is governing in Damascus”. He further commented on a deal between Delta Crescent Energy, a U.S. company, and Syrian Democratic Forces (SDF) and maintained that “we are not involved in the commercial decisions of our local partners… The U.S. government doesn’t own, control or manage oil resources in Syria”.

The U.S. designated fourteen Syrian individuals and entities pursuant to the Caesar Syria Civilian Protection Act (Caesar Act). The same day, the U.S. special envoy for Syria, commenting on Iran’s “military cooperation agreement” with Damascus, asserted that “such military aid to the Assad regime, violates the Caesar Act… The Iranian regime’s pledge to export military equipment to Syria is in blatant defiance of the UN arms embargo under UN Security Council Resolution 2231, and it’s a further demonstration of why we in the U.S. think it’s an imperative that the Security Council must act to extend the arms embargo on Iran” beyond October. He further maintained that “the Iraqi militant groups that are sponsored by the Iranian regime, have been dealing with the Syrian regime in a way that would clearly violate… the spirit of the Caesar Act as well as UN Security Council resolutions”.

Iran’s military chief of staff, Mohammad Baqeri, met with the Syrian Minister of Defence in Damascus and inked “a comprehensive military cooperation agreement”. Baqeri reportedly expressed Tehran’s commitment to “strengthen Syria’s air defence systems in line with the reinvigoration of military cooperation between the two countries”, and said the deal “will increase our determination for joint cooperation to confront the U.S. pressures”. The following day, Baqeri met with Syrian President Bashar al-Assad, who remarked that “this agreement reflects the strategic level of relations between Iran and Syria”. A U.S. military spokesperson subsequently asserted that “the mission of U.S. forces in Syria today remains the same as it was when they first began operations in 2014… U.S. service members will continue to execute the Defeat ISIS mission in Syria, working in conjunction with vetted local forces in northeast Syria and around Al-Tanf Garrison”.

Meeting with Russian and Turkish counterparts under the “Astana Process” talks over Syria, President Rouhani asserted that U.S. sanctions against Syria were “economic terrorism” and pledged that Iran “will continue to support the people and the legitimate government of Syria with greater power. He went on to argue that “the illegitimate presence of the occupying forces of the U.S. regime on Syrian soil has become a destabilising factor for Syria and the entire region, and is plundering natural resources of the country by increasing its illegal military bases in Syria's oil-rich in the eastern Euphrates”. Rouhani further condemned “the increasing scope of the Zionist Regime's [ie, Israel’s] aggression on Syrian soil, and maintained that Israel’s “actions along with the occupation of the Golan Heights have been a factor in destabilising and threatening the peace and security of the region, and the occupying regime will face its consequences”. The meeting concluded with a joint statement emphasising that “there could be no military solution to the Syrian conflict and that it could only be resolved through the Syrian-led and Syrian-owned, UN-facilitated political process in line with the UN Security Council Resolution 2254”. It further recognised “Israeli military attacks in Syria as destabilising and violating the sovereignty and territorial integrity of this country and intensifying the tension in the region”.

Prime Minister Netanyahu opined that “three main challenges are before us, and we are taking action without respite against them: First, we are taking constant action against the efforts of Iran and its proxies to entrench militarily in Syria. The Iranian military must leave Syria. Second, we are taking action against the efforts of our enemies to develop precision missiles in Syria, Lebanon and other areas. Third, and most importantly, we will not allow Iran to attain nuclear weapons”. “Iran is continuing to lie to the international community in its effort to achieve a bomb”, Netanyahu argued. “I have been claiming this for years and today the International Atomic Energy Agency, the IAEA, understands this”. He further affirmed that “we regard with utmost seriousness the threats of destruction against Israel by Iranian and pro-Iranian elements… Whoever tries to attack us places himself in very great danger”.

Syrian state media reported that “hostile air targets coming from east and northeast of Palmyra launched a number of missiles on some military sites” in eastern and southern Syria, causing two fatalities and four injuries. Hours later there were further reports that “the Israeli enemy launched a new aggression through which it targeted a number of the Syrian military sites” near Hama.

CENTCOM Commander Kenneth McKenzie indicated that “what we're committed to doing in Syria is working with our SDF partners to continue to pursue the remnants of ISIS that exist up and down the Euphrates River Valley, so at the same time, set the conditions for long term stability east of the Euphrates River”. He also noted: “I've been given no direction to pull back right now, and I don't know when that would occur, under what conditions that would occur”.

The sanctions provisions of U.S. “Caesar Syria Civilian Protection Act of 2019” (the Caesar Act) went into effect. Secretary of State Mike Pompeo announced that “the Treasury Department and State Department are releasing 39 designations under the Caesar Act and Executive Order 13894 as the beginning of what will be a sustained campaign of economic and political pressure to deny the Assad regime revenue and support it uses to wage war and commit mass atrocities against the Syrian people”. Pompeo further asserted that “we anticipate many more sanctions and we will not stop until Assad and his regime stop their needless, brutal war against the Syrian people and the Syrian government agrees to a political solution to the conflict as called for by UNSCR 2254”. 

The U.S. Special Envoy for the Global Coalition to Defeat ISIS, James Jeffrey, reported that “we are concerned about Daesh [ISIS] elements south of the Euphrates in those areas that the [Syrian] regime and its Iranian and Russian supporters control. There has been a significant increase in attacks, and we’re watching that closely because Daesh sees the entire Iraq/Syria area as one single front”. Jeffrey went on to assert that “there’s been no change in the American position that we’re going to continue to maintain forces as long as the Iraqi government is willing to have U.S. and coalition forces present in the country until the enduring defeat of Daesh is accomplished, and it’s not yet accomplished”. He also noted that in Iraq “NATO has taken the decision to expand its current level and current kind of activities which are higher-level headquarters coordination, coaching, training, that sort of thing”.

The foreign ministers of the Global Coalition to Defeat Daesh/ISIS Small Group issued a communique reiterating their “shared determination to continue the fight against Daesh/ISIS in Iraq and Syria, and to create conditions for an enduring defeat of the terrorist group, which remains the Coalition’s sole purpose”. The ministers also “welcome[d] the establishment of a new government in Baghdad, and look[ed] forward to engaging in a fruitful dialogue with the government of Iraq on our joint endeavor to maintain pressure on Daesh/ISIS”. “In Syria, the Coalition stands with the Syrian people in support of a lasting political settlement in accordance with UN Security Council Resolution 2254”, the statement added. Speaking at the meeting, U.S. Secretary of State Mike Pompeo addressed Iraqi Prime Minister Mustafa al-Kadhimi by saying that “we are all committed to your success in support of the enduring defeat of ISIS”, also noting that “we’re sharing the financial burden of Iraq’s immediate recovery”.  

The U.S. Special Representative for Iran, Brian Hook, indicated that “we have seen some tactical displacement of Iranian troops. We see both Russia and Syria recognising the incentives for Iranian troops and forces under Iranian command and control to leave Syria… That has been a condition of American and the international community providing reconstruction assistance”. Hook added that Iran “is an obstacle… to moving along toward a post-conflict political process. So we think that there are increasing incentives for Iran to leave Syria”. Relatedly, the Israeli military reported “a backward movement [of Iranian/Iranian-backed forces] from various locations to other locations that are further away and in reduced numbers”, assessing the shift to be “not massive, not underwhelming” yet “undeniable”.

Outgoing Israeli Defence Minister Naftali Bennett confirmed that “we have intensified the scope of the attacks against Iranian forces in Syria. We’ve made it clear by our actions that there’s no place protected from us. There’s no safe place for those who try to attack the State of Israel”. He further argued that “Iran has in fact started a process of withdrawing from Syria, but we’ve got to finish the job… We have to increase the diplomatic, economic, military and technological pressure, as well as operate in other realms”. The same day, Iran’s diplomatic spokesperson asserted that “we are in Syria to help them fight terrorism… our attendance in Syria does not concern the U.S. and the Zionist regime [ie, Israel] at all”.

A senior U.S. diplomat indicated that “Iran has been persistent in its efforts to establish this beachhead basically on Israel’s border and to bring in advanced weaponry and assets targeting Israel and moving equipment… through Syria to Hizbollah with this sort of land bridge. We see repeatedly, oftentimes with no claims of responsibility, that these assets are being hit with great regularity, just pounded, and it would make sense at a certain point that Iran would want to cut its losses and downsize its presence there just because it’s increasingly costly to them in terms of life and property”. The official added that the Iranians “would be well advised to start using some of this investment in this military infrastructure in Syria and with Hizbollah to start spending some of that money on their own people who are suffering terribly from COVID”.

The U.S. Special Representative for Syria Engagement, James Jeffrey, confirmed that “we see some Iranian movement around Syria pulling back from areas where the Israelis have struck them. We’ve also seen a withdrawal of Iranian-backed militias – some Hizbollah, some from other countries. But this may be chalked up to a relative lull in the fighting”. He further noted that “what we have not seen… is any strategic Iranian commitment not to try to use Syria both as a second launching pad for long-range weapons against Israel and as a conduit – the famous Shiite Crescent – on to provide Hizbollah more lethal and more modern precision-guided missiles, again, to threaten Israel. That would be the big change”. Jeffrey added that “our policy right now is to restore the situation in 2011 before the conflict began, and that would eventually lead to all of the other military forces that have entered leaving. Ones were most interested in, of course, are the Iranians and the Iranian-commanded militias”.

U.S. Secretary of State Mike Pompeo indicated that “we have been very clear to the Assad regime all along, and to the Russians in Syria: the Iranians need to leave. They need to leave not only the south west corner that has a direct and real impact on Israel and risks to the Golan, but more broadly throughout the country”. He further argued that “the very terror regime that we talk about in the Islamic Republic of Iran has got a campaign that supports what Assad has done that has brutalised and destroyed the lives of hundreds of thousands, caused six or seven million people to have to flee Syria. The Iranian regime is responsible for that in the same way that the Syrian regime is”.

Amidst a series of suspected Israeli airstrikes in Syria, Israeli Defence Minister Naftali Bennett asserted that “we are determined, more determined [than Iran], and I can tell you why — for Iran, Syria is an adventure happening 1,000km away from home. For us, it’s our lives”. He further warned that “Iranian soldiers who come to Syria and operate there… are putting their lives at risk, they are paying that price and will continue to do so. We will not give up and we will not allow the establishment of an Iranian forward operating base in Syria”. In related comments, an unnamed Israeli defence official assessed that “Syria is paying a growing price for the Iranian presence in its territory, for a war that isn’t [Syria’s]. Iran has turned from an asset to Syria into a burden”.

Foreign Minister Javad Zarif met with President Bashar al-Assad and other senior Syrian officials during a visit to Damascus. Zarif told Assad that “the U.S.’s true intentions have come to light with regards to its refusal to lift unfair sanctions against nations during tough times of fighting” COVID-19, and the two sides discussed bilateral and regional matters including the Astana Peace Process. The U.S. Special Representative for Syria Engagement, James Jeffrey, reacted to Zarif’s trip by asserting: “if Iran were truly concerned about the health and safety of the Syrian people, it would support the UN-led political process under UN Security Council Resolution 2254 and withdraw IRGC, Hizbollah and other terrorist forces under its command from the entirety of Syria… Iran's only contributions to Syria have been violence and instability”. He went on to stress that “we continue to offer humanitarian assistance to help address the coronavirus outbreak, while the Assad regime, Russia and Iran obstruct aid and starve the Syrian people of food and medicine”. 

Israeli Minister of Defence Naftali Bennett indicated that “we are seeing the initial indications of Iran weakening and considering a new tack in Syria”. He added that “[Iranians] are sending forces in order to establish a presence there to exhaust us, but we are turning this disadvantage into an advantage. We have intelligence and operational superiority, and we are telling the Iranians clearly: Get out of Syria… we are moving from a defensive position to an offensive position – to weaken, to exhaust, to tire and wear out the head of the octopus [ie, Iran] in order to weaken its arms”.

Responding to statements by senior Israeli officials about countering Iran in Syria, Iran’s diplomatic spokesperson asserted that “Iran will not compromise and hesitate for a moment to defend its presence in Syria and also defend its national security and regional interests. Consequently, Iran will give a decisive and crushing response to any aggression or stupid act by the Zionist regime [ie, Israel]”.

Israeli Defence Minister Naftali Bennett assessed that “for years on end, we have fought against the Iranian tentacles in Lebanon, Syria and the Gaza Strip, but we have not focused enough on weakening Iran itself. Now we are changing the paradigm, we are now engaged in a continued effort to weaken the Iranian octopus through economic, diplomatic and intelligence measures, as well as with military means and various other approaches”. Bennett further addressed Iran and stated: “you have no business being in Syria, and so long as you continue to build terrorist bases there, we will continue to hurt you even further”.

Iranian Foreign Minister Javad Zarif met with the UN Special Envoy for Syria, describing a “political solution as the only way out of the crisis” and underscoring “Tehran's full preparedness for any cooperation within the framework of respecting the sovereignty, independence, unity and territorial integrity of Syria”.

Syrian state media alleged that “Israeli warplanes perpetrated a new aggression on T4 airport from the direction of al-Tanf region… The army air defenses immediately intercepted the hostile missiles and shot down a number of them, meanwhile, four missiles reached the targeted area and the damages were limited to materials”.

In a meeting with the Syrian prime minister, Iranian Supreme National Security Council Secretary Ali Shamkhani emphasised that “as long as terrorist forces of the U.S. stay in the west Asia region, this region will experience no stability, peace or sustainable security… expulsion of the wicked U.S. is possible through unity of regional nations and governments”.

The head of the IRGC's Qods force, Qasem Soleimani, was killed in a U.S. strike in Baghdad. The U.S. Department of Defense confirmed that "at the direction of the President, the U.S. military has taken decisive defensive action to protect U.S. personnel abroad by killing Qasem Soleimani”, adding that "Soleimani was actively developing plans to attack American diplomats and service members in Iraq and throughout the region". Iran confirmed Soleimani’s death, and the IRGC said that four other Qods force members along with five Iraqis, notably including a senior Hashd official, were also killed in the operation. Iranian Supreme Leader Ali Khamenei subsequently asserted that "enemies should bear in mind that the Islamic Republic of Iran will take tough revenge on criminals over the martyrdom of General Soleimani".

The Syrian foreign minister alleged that “the U.S., using its illegal military base in Al-Tanf, sent drones to Homs and committed air strikes by them against the oil refining infrastructure” four days earlier.

President Trump signed the “Caesar Syria Civilian Protection Act of 2019” (the Caesar Act). In a statement, Secretary of State Pompeo indicated that the act “provides the U.S. tools to help end the horrific and ongoing conflict in Syria by promoting accountability for the Assad regime. It also holds accountable those responsible for the widespread death of civilians and for numerous atrocities including the use of chemical weapons and other barbaric weapons”. Pompeo added that “the law provides for sanctions and travel restrictions on those who provide support to members of the Assad regime, in addition to Syrian and international enablers who have been responsible for, or complicit in serious human rights abuses in Syria”.

Speaking alongside U.S. Secretary of State Mike Pompeo, Prime Minister Netanyahu remarked that “we have been fortunate that President Trump has led a consistent policy of pressure against Iran. Iran is increasing its aggression as we speak even today in the region. They’re trying to have staging grounds against us and the region from Iran itself, from Iraq, from Syria, from Lebanon, Gaza and Yemen, and we are actively engaged in countering that aggression”. Netanyahu further maintained that “Iran’s aggression is growing, but its empire is tottering. And I say let’s make it totter even further”. Secretary Pompeo, citing unrest in Iraq, Lebanon and Iran, stated that “some of these are people that are seeking freedom and a reasonable way to live, and they recognise the threat that is posed by the kleptocrats that are running the Islamic Republic of Iran”.

Addressing a Global Coalition to Defeat ISIS Small Group Ministerial meeting, Secretary of State Mike Pompeo asserted that “we’re watching the space once occupied by this fraudulent caliphate [ie, ISIS] like a hawk. That’s why we’re maintaining our residual presence at Tanf, in southern Syria, and our capacity to conduct air operations. We’ve repositioned some our troops in north east Syria and in the broader region as well, to make sure that ISIS will never get a second wind and to prevent ISIS from recapturing the oil fields”. “We are continuing to pursue a diplomatic resolution of the Syrian conflict with UN Security Council Resolution 2254 as the guide so that stability can, one day, return to this war-torn land”, Pompeo added. The coalition also issued a joint communique.

U.S. Secretary of Defense Mark Esper stated that “our mission [in Syria] is the enduring defeat of ISIS. We're going to have about 500 to 600-ish troops there, at the end of the day. We're still moving troops out of northeastern Syria”. In related remarks, a U.S. senior official, referring to oil fields around Deir al-Zour, noted that “the oil is – has been, for the last four years, managed by our partner, the civilian side of our partner operation, the SDC [Syrian Democratic Council]… And we have every expectation they will be continuing to do that without any interference from us”. “Our role”, he added, “is one of ensuring that they’re not bothered by anybody in continuing to do what they’ve been doing for the last four years”.

A senior U.S. defence official indicated that “the military mission in Syria continues. It is the defeat of ISIS, like it has been since 2014, shoulder-to-shoulder with our SDF [Syrian Democratic Forces] partners”. He further clarified that “the securing of the oil fields is a subordinate task to that mission, and – and the purpose of that task is to deny ISIS the – the revenues from that oil infrastructure”. Another defence official asserted that “everyone in the region knows where American forces are. We're very clear with anyone in the region in working to deconflict where our forces are. If anyone – we work to ensure that – that no one approaches or has – shows hostile intent to our forces, and if they do, our commanders maintain the right of self-defence”. 

Syria and Russia jointly issued a statement asserting that “in southern Syria, the U.S. continues to hold the illegally occupied 55-km zone around Al-Tanf and prevent the dissolution of the Rukban refugee camp”. “We urge the entire international community to exert pressure on the U.S., which continues to violate the international law by its illegal presence in Syria, and to oblige them to withdraw completely troops from the sovereign Syrian Arab Republic”, the statement added.

The U.S. State Department in its Country Reports on Terrorism 2018 assessed that “the [Syrian] regime continued to provide weapons and political support to Hizbollah and continued to allow Iran to rearm the terrorist organisation”. It further contended that “the Assad regime’s relationship with Hizbollah and Iran grew stronger in 2018 as the regime became more reliant on external actors to fight opponents and secure areas”.

Iranian Foreign Minister Javad Zarif stated that “we will be in Syria as long as the Syrian government and people want”. He went on to say that “it seems that the U.S. is staying to protect the oil and at least President Trump is honest to say what the U.S. intends to do”.

Reaffirming that “the United States will retain control of oil fields in northeast Syria”, U.S. Defence Secretary Mark Esper stressed that “we will respond with overwhelming military force against any group that threatens the safety of our forces there”. Responding to a question on whether this mission “include[s] denying access, preventing Russian or Syrian forces”, Secretary Esper went on to assert that “the short answer is yes, it presently does, because in that case we want to make sure that SDF does have access to the resources in order to guard the prisons, in order to arm their own troops, in order to assist us with the Defeat ISIS mission. So that's our mission, is to secure the oil fields”. Esper also reaffirmed that “we also were given the earlier directive to retain forces at the Al-Tanf garrison”.

U.S. Secretary of Defence Mark Esper indicated that “the U.S. will maintain a reduced presence in Syria to deny ISIS access to oil revenue as we reposition for the next phase of the Defeat ISIS campaign”. Esper added that “ultimately, we always intended, as the president directed, to maintain a presence at the Al-Tanf garrison”. He also revealed that “we are now taking some action… to strengthen our position at Deir el-Zour, to ensure that we can deny ISIS access to the oil fields”, which “will include some mechanized forces”. Previously, via Twitter, President Trump had stated that “perhaps it is time for the Kurds to start heading to the oil region”.

The U.S. Department of Treasury issued sanctions against “one entity, three individuals and five vessels participating in a sanctions evasion scheme to facilitate the delivery of jet fuel to Russian forces operating in Syria”. In related comments, Secretary of State Pompeo stated that “the U.S. has concluded that the Assad regime used chlorine as a chemical weapon on May 19th in an attack at Latakia province, Syria… the U.S. will not allow these attacks to go unchallenged, nor will we tolerate those who choose to conceal these atrocities”.

Secretary of State Pompeo stated that “the U.S. supports UN efforts to end military violence in Syria. Ongoing violence - fuelled by Iran and Russia - is exacerbating Syria’s dire humanitarian situation and must cease for a political solution to take root”.

Iran’s President Rouhani remarked that “it is strange that the enemies of the region have not yet understood the power of the regional nations’ resistance… instead of admitting that Lebanon’s Hizbollah has high capabilities and power both in scientific and military knowledge and bravery in the field, or that a part of brave young people of Iraq have liberated different cities across the country from the hands of terrorists, and instead of admitting to the growth and greatness of nations like Syria and Yemen, they are seeking to accuse others”.

President Rouhani remarked that “there is only a political solution to the Syrian crisis, and this can only be achieved through constructive interaction and participation by all Syrian people”. He further argued that “U.S. troops must leave the area as soon as possible and that the Syrian government's control must expand in the east and north of the Euphrates, as in the rest of Syria”.

The U.S. Treasury Department announced sanctions against "sixteen individuals and entities associated with an international network benefiting the Assad regime", including a pair of companies based in Lebanon that "facilitated shipments of Iranian-origin petroleum to Syria".

Secretary Pompeo reaffirmed that “our efforts in Syria are aimed at a political resolution … UN Security Council Resolution 2254 is the guidepost”. Pompeo went on to refer to “the work that we’ve done with the Turks in Manbij, west of the Euphrates River, and we are attempting to set up a system… call it a buffer zone, call it what you will – that will reduce risk of terrorists attacking from Syria into Turkey and reduce risks that Turkey will come south and disrupt Kurdish activity inside of Syria”.​​​​​​

The U.S.’ diplomatic spokesperson asserted that “our maximum pressure campaign on Iran is designed to deny the Iranian regime, the world’s foremost state sponsor of terrorism, the means to conduct its destructive foreign policy. Our campaign is working”. She elaborated that “the campaign is starving Iran’s proxies of the funds they rely on to operate on behalf of the regime”, citing examples including Hizbollah, Hamas, the Syrian government and Shiite militias in Iraq. She went on to affirm that “we will continue to apply maximum pressure on the Iranian regime to deny it the means to conduct its destructive foreign policy and compel the regime to negotiate a comprehensive new deal that addresses the full scope of its malign behaviour”, while also indicating that “there is a path forward and we will talk tomorrow if they would like to see the bright future that we believe is there for the Iranian people”. The spokesperson further indicated that “we do not want a war with Iran. We want to de-escalate with Iran. In fact, what we seek is to end economic sanctions, to end the maximum pressure campaign”.

The U.S. special representative for Syria, James Jeffrey, told the House Foreign Affairs Committee that “the [Trump] administration is pursuing three mutually reinforcing whole-of-government strategic objectives in Syria – the enduring defeat of ISIS, the removal of all Iranian-led forces from Syria and the resolution of the Syrian crisis through a political solution in line with UN Security Council Resolution 2254”. “The Iranian regime’s malign activity has left us no choice but to pursue the withdrawal of all Iranian-commanded forces from the entirety of Syria”, Jeffrey elaborated. “Iran’s reckless behaviour makes the situation in Syria more dangerous… Iranian-backed forces use bases inside Syria to participate in violence again[st] the Syrian people and launch attacks against Israel”. He added that “Iran and its proxies threaten U.S. national security by sowing instability in the region that exacerbates tensions between communities and provides space for terrorist groups to thrive”.

U.S. Central Command indicated that remarks by a senior military official in the U.S.-led counter-ISIS campaign, who had stated that "there's been no increased threat from Iranian-backed forces in Iraq and Syria", "ran counter to the identified credible threats". CENTCOM's statement added that "OIR [Operation Inherent Resolve] is now at a high level of alert as we continue to closely monitor credible and possibly imminent threats to U.S. forces in Iraq". 

A senior U.S. military official asserted that "we're going to continue to reach out to our partners and friends in the region to ensure that we make common cause against the threat of Iran... I believe we'll have the resources necessary to deter Iran from taking actions that will be dangerous". He went on to indicate that "over the long term, we're going to reduce our forces in Syria, we recognise that, that's the guidance in which we're operating... that will be something that we will look at very carefully as we go forward". The U.S., he added, would maintain "a long-term presence in Iraq, focussed on the counter-terror mission". 

Foreign Minister Javad Zarif traveled to Damascus for meetings with President Assad and other senior Syrian officials. 

A senior Syrian official asserted that "Syria will liberate the occupied Golan by all means and all choices are on the table". He also argued that "the U.S. administration lies with regard to pulling out its troops, which are illegitimately deployed in Syria, and it isn't our duty to teach them to be honest". 

The U.S. added "dozens of new vessels involved in illicit oil shipments" from Iran to Syria in an update to a November 2018 advisory. A senior Treasury Department official noted that "the U.S. has made it clear to the maritime shipping community that we will not tolerate the use of petroleum as a mechanism to finance rogue regimes in Iran and Syria", adding that "as Iran and Syria attempt to adapt their illicit tactics and shift to new vessels, we will continue to provide these updates to the shipping community". 

The U.S. special representative for Iran, Brian Hook, noted that "we know historically that Iran has given Hizbollah an average of $700 million a year... we have seen evidence of the impact [of U.S. sanctions] when the leader of Hizbollah makes a public appeal for charity. It speaks for itself. This is the kind of impact that we want". He added that "we know that we have denied the [Iranian] regime even in the short amount of time [since sanctions came into effect] many billions of dollars in revenue", and underscored that the U.S. held "talks with any government where we see sanctions violations or even potential sanctions violations". Hook went on to underscore that "we are... committed to ensuring that troops under Iranian command are out of Syria", and suggested Iran had a "vastly-under reported role in Yemen" despite having "no legitimate interest" in the country. "Giving [Iran] a foothold in Yemen", Hook argued, "allows them to threaten two straits of international commerce". 

Iran's military chief of staff met with his opposite numbers from Syria and Iraq, pledging that "measures taken by the three countries will continue until terrorists are fully defeated". He also met with the Syrian president, Bashar al-Assad, in Damascus. 

During a trip to Syria, Iran's military chief of staff argued that "all foreign troops who are present in Syria without coordinating with the Syrian government will have to leave the country sooner or later". 

CENTCOM commander Joseph Votel posited that "the U.S. withdrawal from Syria represents the most dynamic shift in the environment since ISIS lost its ability to govern major population centres and fight as a conventional force and could trigger a renewed race for influence, control, and for some, survival". He further stated that "Israel's legitimate concerns about Iran's increasingly provocative actions in Syria, particularly the transshipment of advanced weapons systems into and through Syria, are driving increasingly forward-leaning Israeli military actions". 

President Trump replied to a 22 February letter from members of Congress calling for "a small American stabilising force in Syria" by bracketing a paragraph about ensuring "that ISIS never returns, that Iran is not emboldened" and noting "I agree 100 per cent - all is being done". 

President Trump assessed that "as of probably today or tomorrow, we will actually have 100 per cent of the [ISIS] caliphate in Syria... And we'll leave a small group of guys and gals. But we want to bring our people back home". 

Qods force commander Soleimani described Syrian President Bashar al-Assad's 25 February trip to Tehran as a "celebration of victory", adding that "you saw how Assad hugged the [Supreme] Leader with love, like a son who has been departed from his father. This is not a minor thing". Soleimani also assessed that "the most secure borders of our country is the common border with Iraq, and our friends are ruling the country". 

President Rouhani maintained that "we have achieved good victories in the political and international stages, and we have done great things in the region, parts of which were on the shoulders of the IRGC, the foreign ministry and the economic sectors". He added that the 25 February visit of President Bashar al-Assad "indicates that if we stand by each other, we will be successful". 

Syrian President Bashar al-Assad traveled to Tehran for meetings with senior Iranian officials. Supreme Leader Ali Khamenei asserted that "Syria... managed to stand strong against a big coalition of the U.S., Europe and their allies in the region and victoriously come out of it". He also warned that "the question of a buffer zone in Syria that the Americans are trying to create is one of their dangerous plots that must be firmly rejected and opposed". "Iran and Syria", Khamenei added, "are strategic allies and the identity and power of Resistance depends on their continuous and strategic alliance, because of which the enemies will not be able to put their plans into action". President Rouhani pledged that "Iran will stand by the Syria government and people like before". 

Iran's Supreme National Security Council Secretary, Ali Shamkhani, maintained that "we will stay in Syria and fight against terrorism as long as the legitimate Syrian government would make such requests". Addressing Israel's airstrikes, Shamkhani posited that "Israel is clearly taking steps to serve the interests of terrorists and to counter the Syrian government and army". "We severely responded to the [Israeli] attack on T4 and dealt a heavy blow to them", Shamkhani remarked. "We have made arrangements to protect our red line in the area of human casualties caused by any act of aggression and invasion". He also predicted that "we will soon witness a major upheaval in upgrading the deterrent power of resistance in Syria. I believe that the Zionist regime's officials, particularly their military and intelligence officials, are well aware of this issue. The method for tackling their Zionist regime's attacks on Syria and the axis of resistance in 2019 will be significantly different from the combat methods in the past". "We have accomplished more than 90 per cent of our objectives [in Syria]", Shamkhani maintained. "Thus, the Israeli punitive strikes have had no strategic impact and the resistance has pressed ahead with its activities".  

A U.S. official indicated that that approximately 200 U.S. troops would remain deployed at the al-Tanf garrison even as the U.S. proceeded to significantly reduce its military presence across Syria.

The White House announced that following the withdrawal of U.S. forces, "a small peacekeeping group of about 200 will remain in Syria for a period of time". However, the following day media reports clarified that the figure may actually be 400. 

President Rouhani met with his Turkish and Russian counterparts for discussions on Syria. In a press conference, he suggested that "if the U.S. retreats its forces from Syria, based on our intelligence we know that they will continue to meddle in Syria". Rouhani also posited that "illegal interference in Syria by the Zionist regime [i.e. Israel] is a source of concern for the people of this country and other nations in the region. [The] Israelis bomb anywhere in the region and fly on Lebanese and Syrian soil whenever they wish, and unfortunately, the UN and global authorities are silent about these continued acts of aggression in Syria". 

Secretary Pompeo, in Warsaw for the Ministerial to Promote a Future of Peace and Security in the Middle East, described the proceedings as "absolutely historic... the first time in a quarter of a century that you had the prime minister of Israel in the same room talking about threats in the Middle East with senior Arab leaders from all across the Middle East". "This gathering is certainly about Middle East peace and stability," he explained. "You can't talk about that without talking about the threat from the Islamic Republic of Iran, whether it's Hizbollah, Hamas, the Houthis - I call them the three H's - whether it's their work against the Iraqi government... whether it's what they're doing in Syria today". Pompeo also remarked that "we don't expect the Iranian people to support the U.S. We expect them to take care of their own country... we want the Iranian people to have the opportunity to live in a prosperous, peaceful society and one that is controlled by their desires, their wishes. And if we can get that, I am very confident that these behaviours that we see in Iran will change dramatically". On Yemen, Pompeo stressed that "we have two problems - three problems really. The first problem is al-Qaeda... the second problem is Iran continuing to fund the Huthis... it provides missiles to the Huthis that they launch into airports in Saudi Arabia and the Emirates". 

In remarks to a ministerial meeting of the counter-ISIS coalition, President Trump indicated that "the U.S. military, our Coalition partners and the Syrian Democratic Forces have liberated virtually all of the territory previously held by ISIS in Syria and Iraq. It should be formally announced sometime probably next week that we will have 100 per cent of the caliphate". He went on to state that "as countries in the region and across our Coalition step up their commitments, as we continue to destroy the remnants - that's all they have, remnants. But remnants can be very dangerous".